A few things:
1. Will Medel, and Santon play? I would probably rest both of them, esp Medel as he had been playing non-stop. It would be interesting to see who takes Medel's place, Kondogbia or Melo. Either way, I think Ansaldi will debut this match.
2. Will Perisic start? again, depends on how serious his case of muscle fatigue was. I wouldn't mind seeing Eder start and give Perisic extra time to recover for the Bologna match.
3. Who will replace Banega after his red? My heart wants JoJo, but my head thinks Mario will play further upfield.