I think Milan will try to clutter the midfield. They will start with at least 4 midfielders, possibly Bertolacci-Kucka-De Jong-Bonaventura. Which means this will end up like most derbies, a tight midfield battle.
I am not sure Perisic, Ljajic, Melo and Telles will all be ready to start immediately... not doubting their fitness, but it can be dangerous to debut 4 players in one game, specially since they have all just arrived after the season started. My guess would be that Mello and Telles will start, as the forwards probably need more time to gel.
Mancini may consider continuing with a 4 man midfield, and the perhaps introducing Perisic/Ljajic in the 2nd half if need be. That might be the more sensible approach.
Jovetic - Icardi
Brozovic
Kondogbia ----- Guarin
Melo
Telles - Murillo - Miranda - Santon
Handanovic
Perisic to come in for Guarin or Brozovic in the 2nd half.
I know we are all very eager to see a 4 man attacking line up including Perisic and Ljajic, specially to fuck AC Merda, but this game may be too soon. Better safe than sorry.
I am expecting a 1-1 draw.