I'd give Handanovic his last match (I guess), get him closer to the record. Can't tell if he's going to join some mid-table or newly promoted team in Serie A next year to get his appearance numbers up or retires, so whatever it is, let help him increase his tally.
------------Handanovic
------DDA-----De Vrij-----Bastoni
Bellanova-----------------------------Gosens
------Asllani---Brozovic----Hakan
--------------Dzeko-----Lukaku
I guess Gagliardini over Asllani makes more sense for the coach, and Dzeko-Lukaku doesn't really work, but I'd like to give Barella and Lautaro some rest here, use them in the last 30 minutes or something. And ideally Bastoni subbed off after 60-65 minutes.
Gosens and De Vrij, I'd give 90 full minutes.
Hopefully we see Carboni and Zanotti getting minutes. If Skriniar is ready, I'd give him one last moment as well in the final minutes.